Learn More About Lung Infections in CF Subjects

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There are 70,000 CF patients worldwide and around 30,000 subjects in the US. Cystic fibrosis is an inherited, fatal disorder which affects the lungs and pancreas. It is marked by the production of abnormally viscous mucus resulting in chronic respiratory infections.

 

 

 

 

 

 

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Understanding the microbial flora of the CF respiratory tract is of considerable importance, as patient morbidity and death are primarily caused by chronic respiratory infections. Chronically colonized CF airways are diverse ecosystem that varies greatly in different age groups.

 

 

 

 

Respiratory Germs of CF Patients by Age1-4 

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1. Cystic Fibrosis Foundation Patient Registry: Annual Data Report 2010, 2012
2. Bakare, N., et al. «Prevalence of Aspergillus fumigatus and other fungal species in the sputum of adult patients with cystic fibrosis.» Mycoses 46.1‐2 (2003): 19-23
3. MDR-PA is a multidrug resistant P.aeruginosa
4. MRSA is methicillin resistant S.aureus

Infectious disease treatments are associated with challenges including increasing antimicrobial resistance, limited drug spectrum and these difficulties have instigated novel antimicrobial drug development. It was recently shown that cystic fibrosis patients with chronic MDR-PA, MRSA or mixed bacterial-fungal infection correlates with increased mortality.

TGV-Therapeutics’ primary interest lie in development of inhaled Mul-1867-CF that is effective against antibiotic-resistant microorganisms and  bacterium within a biofilms.